Calcium Channel
Ca2+ channels; Ca channels
Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.
Calcium Channel Isoform Specific Products
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Calcium Channel Inhibitors
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Calcium Channel Agonists
(35)
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Calcium Channel Antagonists
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Calcium Channel Activators
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Calcium Channel Modulators
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Calcium Channel Chemical
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Calcium Channel Inducers
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Calcium Channel Controls
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Calcium Channel Ligands
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Calcium Channel Related Products (1225)
Related Products (1225)
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Antibodies (29)
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Related Compound Screening Libraries (1)
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Calcium Channel Isoform Comparison
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Carboxyamidotriazole Orotate (Standard)
0 ImagesSynonyms: L-651582 Orotate (Standard); CAI Orotate (Standard)Carboxyamidotriazole (Orotate) (Standard) is the analytical standard of Carboxyamidotriazole (Orotate). This product is intended for research and analytical applications. Carboxyamidotriazole Orotate (L-651582 Orotate) is the orotate salt form of Carboxyamidotriazole (CAI), an orally bioavailable signal transduction inhibitor. Carboxyamidotriazole Orotate is a cytostatic inhibitor of nonvoltage-operated calcium channels and calcium channel-mediated signaling pathways. Carboxyamidotriazole Orotate shows anti-tumor, anti-inflammatory and antiangiogenic effects.
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Bupivacaine (Standard)
0 ImagesBupivacaine (Standard) is the analytical standard of Bupivacaine. This product is intended for research and analytical applications. Bupivacaine is a NMDA receptor inhibitor. Bupivacaine can block sodium, L-calcium, and potassium channels.Bupivacaine potently blocks SCN5A channels with the IC50 of 69.5 μM. Bupivacaine can be used for the research of chronic pain.
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Nisoldipine-d7
0 ImagesCat. No.: HY-17402S2CAS No.: 1189718-34-0Nisoldipine-d7 (BAY-k 5552-d7) is the deuterium labeled Nisoldipine. Nisoldipine(BAY-k 5552) is a calcium channel blocker belonging to the dihydropyridines class, specific for L-type Cav1.2 with IC50 of 10 nM.
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Liguzinediol
0 ImagesCat. No.: HY-121864CAS No.: 909708-65-2Liguzinediol is a protein phosphatase 1 (PP1) and protein phosphatase 2A (PP2A) inhibitor that enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a). Liguzinediol reduces the dephosphorylation level of phospholamban and increases the phosphorylation levels of phospholamban at serine-16 and threonine-17 sites. Liguzinediol exerts positive inotropic effects in rat hearts both in vivo and in vitro, and reverses caffeine-induced decrease in myocardial contractility in isolated rat hearts. Liguzinediol can be used for the research of heart failure.
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Dronedarone-d6
0 ImagesCat. No.: HY-A0016S3CAS No.: 1132693-87-8Synonyms: SR 33589-d6Dronedarone-d6 (SR 33589-d6) is deuterium labeled Dronedarone. Dronedarone (SR 33589), a derivative of amiodarone (HY-14187), is a class III antiarrhythmic agent for the study of atrial fibrillation (AF) and atrial flutter. Dronedarone is a potent blocker of multiple ion currents, including potassium current, sodium current, and L-type calcium current, and exhibits antiadrenergic effects by noncompetitive binding to β-adrenergic receptors. Dronedarone is a substrate for and a moderate inhibitor of CYP3A4.
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Urolithin C (Standard)
0 ImagesCat. No.: HY-135897RCAS No.: 165393-06-6Urolithin C (Standard) is the analytical standard of Urolithin C. This product is intended for research and analytical applications. Urolithin C, a gut-microbial metabolite of Ellagic acid, is a glucose-dependent activator of insulin secretion. Urolithin C is a L-type Ca2+ channel opener and enhances Ca2+ influx. Urolithin C induces cell apoptosis through a mitochondria-mediated pathway and also stimulates reactive oxygen species (ROS) formation.
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TGR5 Receptor Agonist (Standard)
0 ImagesSynonyms: CCDC (Standard)TGR5 Receptor Agonist (Standard) is the analytical standard of TGR5 Receptor Agonist. This product is intended for research and analytical applications. TGR5 Receptor Agonist (CCDC), a potent Takeda G protein-coupled receptor 5 (TGR5; GPCR19) agonist, shows improved potency in the U2-OS cells and melanophore cells with pEC50s of 6.8 and 7.5, respectively. TGR5 Receptor Agonist can induce peripheral and central hypersensitivity to bladder distension in mice, and increase intracellular Ca2+ concentration. TGR5 Receptor Agonist can also reduces food intake and improves insulin responsiveness, in diet-induced obese mice. TGR5 Receptor Agonist can be used to research diabetes, bladder hypersensitivity and anti-obesity.
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SB-237376 free base
0 ImagesCat. No.: HY-108163CAS No.: 179258-59-4SB-237376 (free base) is a potassium and calcium channel blocker. SB-237376 (free base) can inhibit the rapidly activating delayed rectifier potassium current I(Kr) (IC50 is 0.42 μM), and at high concentrations, it blocks the L-type calcium current I(Ca,L). In the rabbit ventricular model, SB-237376 (free base) can induce early afterdepolarizations (EADs) at a concentration of 3 µM. Compared to other IKr inhibitors such as dl-sotalol, SB-237376 has a lower proarrhythmic risk. SB-237376 (free base) holds potential for research in the field of arrhythmia-related diseases.
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Rp-8-Br-cGMPS
0 ImagesCat. No.: HY-135110ACAS No.: 150418-07-8Synonyms: Rp-8-bromo-Cyclic GMPS
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Terflavoxate
0 ImagesCat. No.: HY-106415CAS No.: 86433-40-1Terflavoxate is a flavone derivative with spasmolytic properties. Terflavoxate has Ca2+-antagonistic effect is mainly responsible for Terflavoxate smooth muscle relaxant properties. Terflavoxate has the potential for overactive detrusor research.
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Teludipine hydrochloride
0 ImagesCat. No.: HY-101621CAS No.: 108700-03-4Synonyms: GR53992B; GX1296BTeludipine is a lipophilic calcium channel blocker.
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Tiapamil hydrochloride
0 ImagesCat. No.: HY-101674CAS No.: 57010-32-9Synonyms: Ro 11-1781Tiapamil hydrochloride is a calcium channel blocker.
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ABT-639 hydrochloride
0 ImagesCat. No.: HY-101616CAS No.: 1235560-31-2ABT-639 hydrochloride is a novel, peripherally acting, selective T-type Ca2+ channel blocker.
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Nexopamil racemate
0 ImagesCat. No.: HY-101727CAS No.: 116759-35-4Nexopamil racemate is the racemate of Nexopamil. Nexopamil is a combined Ca2+/5-HT2 antagonist on thrombus formation in vivo and on platelet aggregation in vitro.
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Iganidipine
0 ImagesCat. No.: HY-101685CAS No.: 119687-33-1Iganidipine is a Ca2+ antagonist.
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SM-6586
0 ImagesCat. No.: HY-19062CAS No.: 103898-38-0SM-6586 is a calcium channel antagonist and inhibitor of Na+/H+ and Na+/Ca2+ exchange transport, potentially for the treatment of cerebrovasular diseases and hypertension.
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TDN345
0 ImagesCat. No.: HY-101669CAS No.: 134069-68-4TDN345 is a Ca2+ antagonist, used for the treatment of vascular and senile dementia including Alzheimer's disease.
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Teludipine-d6
0 ImagesCat. No.: HY-101621SCAS No.: 1246833-02-2Teludipine-d6 is the deuterium labeled Teludipine hydrochloride. Teludipine is a lipophilic calcium channel blocker.
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Nefiracetam (Standard)
0 ImagesSynonyms: DM9384 (Standard); DZL-221 (Standard)Nefiracetam (Standard) is a cognition-enhancing agent. Nefiracetam is an activator of nAChR, N-methyl-D-aspartate receptor (NMDAR), mGluR5, PKC, gamma-aminobutyric acid (GABA), and N/L-type Ca2+ channels. Nefiracetam promotes neuroplasticity and enhances neuroprotection. Nefiracetam can be used in Alzheimer's disease, epilepsy, and cerebral ischemia research.
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Trimebutine (Standard)
0 ImagesTrimebutine (Standard) is the analytical standard of Trimebutine (HY-B0380). This product is intended for research and analytical applications. Trimebutine is a multi-target inhibitor and opioid receptor agonist with antimuscarinic activity. Trimebutine inhibits L-type Ca2+ channels and large-conductance calcium-activated potassium channels (BKCa channels), thereby inhibiting extracellular calcium influx and potassium ion efflux. Trimebutine also targets Toll-like receptors, inhibits Toll-like receptor 2/4/7/8/9 signals, and inhibits LPS-induced IRAK1 activation, as well as ERK1/2, JNK and NF-κB activation, thereby exerting anti-inflammatory effects. Trimebutine also induces tumor cell apoptosis by inhibiting the AKT/ERK pathway. Trimebutine also inhibits excessive contraction of smooth muscle and can be used in the study of gastrointestinal disorders such as irritable bowel syndrome (IBS).
